Display # 5101520253050100All 1 "LV mechanical dyssynchrony may act as a modulator of cardiac performance together with heart rate, contractile state, pre-load and afterload.” Brutsaert D. Nonuniformity: a physiologic modulator of contraction and relaxation of the normal heart. J Am Coll Cardiol 1987;9:341-348. 2 "Mechanical dyssynchrony measures of systolic dyssynchony are not affected by load alteration in health, ... they are load independent even in the setting of increased^systolic dyssynchrony resulting from^endotoxin infusion." A'roch R et al. Left ventricular mechanical dyssynchrony is load independent at rest and during endotoxaemia in a porcine model. Acta Physiol. 2009;196:375-383 3 ”Echocardiographic dyssynchrony parameters have no place in denying potentially life-saving treatment or in exposing patients to unnecessary risks and draining health care resources” Hawkins NM, Petrie MC, Burgess MC, McMurray JJ. Selecting patients for Cardiac resynchronization Therapy. The fallacy of echocardiographic dyssynchrony. J Am Coll Cardiol 2009;53:1944-59 4 Left ventricular mechanical dyssynchrony (mechanical inefficiency) correlated markedly inverse with left ventricular energy efficiency and contractile state... The CC technique "allows an analysis of dyskinesia and akinesia at high-time resolution Schreuder JJ, Castiglioni A, Donelli , et al. Acute decrease of left ventricular mechanical dyssynchrony and improvement of contractile state and energy efficiency after left ventricular restoration. J Thorac Cardiovasc Surg 2005;129:123-129. 5 ”Given the modest sensitivity and specificity no single echocardiographic measure of dyssynchrony may be recommended to improve patient selection for CRT” Chung ES, AR Leon, L Tavazzi, et al. Results of the predictors of response to CRT (PROSPECT) trial. Circulation. 2008;117:2608-16. 6 The quantification of mechanical dyssynchrony has important diagnostic value and may help to determine optimal therapy in heart failure (HF). [measured with CD Leycom's PV technology] Kurita T et al. Impact of heart rate on mechanical dyssynchrony and left ventricular contractility in patients with heart failure and normal QRS duration. Eur J Heart Fail. 2007 Jun-Jul;9(6-7):637-43. 7 “Thus it is conceivable that dyssynchrony represents a newly appreciated pathophysiological process that directly depresses ventricular function and ultimately leads to ventricular dilation and heart failure.” Auricchio A, Abraham WT, Cardiac resynchronization therapy: current state of the art: costs versus benefit. Circulation 2004;109:300-307. 8 “Ventricular mechanical dyssynchrony can be measured real-time and operator-independent by the conductance catheter technique.” Steendijk P, Tulner SA, Schreuder JJ, et al. Quantification of left ventricular mechanical dyssynchrony by conductance catheter in heart failure patients. Am J Physiol 2004;286:H723-730.